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Silicon substituted calcium phosphate based bioceramic scaffolds
Karkuszová, Karina ; Šťastná, Eva (referee) ; Novotná, Lenka (advisor)
The theoretical part of this bachelor thesis summarizes the current state of knowledge of bioceramic materials based on calcium, phosphorus and silicon. More specifically, it focuses on calcium phosphates, the demands placed on them, the porosity of 3D foams, and biological properties such as biodegradation and bioactivity. 3D bioceramic calcium phosphate foam doped with silicon appears to be a suitable material for use in biomedical applications. It is the silicon that plays a role in the development of healthy bone and the formation of new tissue. Silicon substitutions are important in the field of investigation because they improve the bioassay of phosphate calcium. In the experimental part, calcium phosphate powders were first prepared by the hydroxyapatite and silica fusion reaction. Selected powder contents were 0; 0.1; 1, 2.5, 5, 10 and 20 wt.% SiO2. The samples were sintered at 1100 °C, 1200 °C and 1300 °C. The second part consisted in the preparation of 3D foams by direct penetration with polyurethane and the subsequent characteristics of phase composition, solubility and bioactivity. Bioceramic foams had a highly porous structure. For 42 days, sample behavior in Tris-HCl and simulated body fluid (SBF) was monitored. The results of the experiment have shown that the samples are bioactive and silicon substitution increases phosphate calcium solubility. Therefore, these materials are potentially useful for biomedical applications
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Fabrication of dental glass-ceramics
Hasalíková, Tereza ; Dlabajová, Lucie (referee) ; Bartoníčková, Eva (advisor)
This bachelor´s thesis deals with the study of glass-ceramic materials and their use in dentistry. Nowadays, studies are placed on health harmless of the material, the biological ability to adapt to the host tissue, mechanical properties, affordability, easy and fast production, aesthetics and quick recovery of the patient. The theoretical part of the work deals with various materials from various input materials used for dental substitutes. Special attention is paid to glass-ceramic and ceramic biomaterials, their preparation, heat treatment and health testing. The experimental part deals with the preparation of powder materials by the sol-gel method. Of the larger number of samples, those were selected for gelation and showed good XRD and heat microscopy results. The selected samples were subsequently subjected to heat treatment to form a glass ceramic material. The products were characterized by XRD phase composition in terms of phase temperature behavior by TG-DTA analysis, heat microscopy and SEM morphology analysis of prepared particle.
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Tailoring of phase composition and microstructure of calcium phosphate scaffolds applied in regenerative medicine.
Pejchalová, Lucie ; Novotná, Lenka (referee) ; Salamon, David (advisor)
Vápenaté fosforečnany jsou nejčastěji využívané keramické materiály v medicíně pro regeneraci kostní tkáně. Vápenaté fosforečnany jsou biokompatibilní, bioaktivní a mezi sebou se odlišují především rozpustností a související degradací v organismu, proto jsou nejčastěji využívány k regeneraci malých defektů nebo jako vrstvy na kovových implantátech. U již zmíněné rozpustnosti materiálu po implantaci, hraje důležitou roli poměr zastoupení jednotlivých vápenatých fosforečnanů, od kterého se pak odvíjí rychlost degradace materiálu v organismu. Tato práce se zabývá vlivem tvarovacích metod na mikrostrukturu a zejména fázové složení vápenatých fosforečnanů. Výchozím materiálem pro pozorování změn ve fázovém složení byl komerční hydroxyapatit, který byl upraven kalcinací při 800 °C po dobu jedné hodiny. Při kalcinaci došlo k vytvoření dvoufázové směsi, obsahující hydroxyapatit a -fosforečnan vápenatý. Tato dvoufázová směs byla poté využita pro přípravu suspenze s plněním 15 obj.%, a také k přímé přípravě polotovarů s různou výslednou mikrostrukturou a fázovým složením. S cílem zjistit vliv procesu byly v této práci porovnány vzorky připravené pomocí metod: freeze-casting, izostatické lisování za studena, uniaxiální lisování a suspenzní odlévání. U polotovarů a slinutých vzorků byla provedena charakterizace mikrostruktury a analýza fázového složení. V práci se potvrdil vliv tvarovací metody na oba stanovené parametry – mikrostrukturu a fázové složení. Nově pak bylo zjištěno, že se zvyšující se hodnotou porozity a velikostí pórů se zvyšuje i zastoupení hydroxyapatitu ve vzorcích. Tento trend byl pozorován u vzorků vykazujících unimodální i bimodální zastoupení velikosti pórů.
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Preparation of large and complex-shaped ceramics parts
Prehradná, Jana ; Pouchlý, Václav (referee) ; Trunec, Martin (advisor)
This bachelor’s thesis deals with research of ceramic materials in field of material engineering. The first part deals with biomaterials, especially bioceramics, its types, properties and its usage. The second part of this thesis deals with transparent ceramics and the third part includes the procedure and method of gel casting. The experimental part is dedicated to production of large and complex shaped components - knee joint, spherical cover and discs with transparent properties. The method of gelcasting was used for samples preparation of this type. The task was not only to produce these samples, but also to find suitable surrounding conditions for the proper course of the entire production process.
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Preparation and properties of machinable ceramic materials
Sláma, Martin ; Matoušek, Aleš (referee) ; Cihlář, Jaroslav (advisor)
The thesis is focused on studying the machinability of ceramic material in dependence on presintering temperature. Alumina was used as an experimental material. The machinability of alumina was observed on samples produced by uniaxial pressing. Presintered and not-presintered disks were machined by cutter. Disks were presintered at 700°C, 800°C, 900°C and 1000°C for one or two hours. Machinability of alumina was tested according to four levels of the milled depth and according to temperature and the effect of dwell.
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Shaping of bioceramic hydroxyapatite scaffolds on micro level
Pejchalová, Lucie ; Novotná, Lenka (referee) ; Salamon, David (advisor)
Due to increasing average age of population around the world, there are more patients who need surgery of musculoskeletal system. In some cases, it is even necessary to implant new bone scaffold or replace joints. Hydroxyapatite is the most frequently used material for its biocompatibility and bioactivity. On the other hand, mechanical properties constraints its use in porous scaffolds. The method providing both good mechanical stability and high porosity is freeze – casting. This method utilises controlled freezing to form lamellar structure. During freezing of slurry, ice crystals grow in direction of temperature gradient. In next step, ice crystals are removed by lyophilisation and lamellar structure is revealed. This structure is relatively unstable and needs to be reinforced by sintering. There are many aspects affecting resulting structure – freezing schedule, slurry concentration etc. We used water/ceramic slurries in various concentrations of hydroxyapatite (7,5 % vol., 10 % vol., 15 % vol. and 20 % vol.). These slurries were used for preparation of porous bone scaffolds. We tried to add 3D mash to form net of channels and we observed favourable changes in porosity. 3D mash was removed during sintering. Resulting bioceramics structure was highly porous (up to 90 %). These scaffolds had an acceptable ration between porosity and mechanical stability, too. We considered, adding of 3D mash, as good way to form channels of desired properties.
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Study of bioceramic materials on the base of calcium phosphates
Kolář, Martin ; Maca, Karel (referee) ; Cihlář, Jaroslav (advisor)
The literature search on the topic of Bioceramic materials focused in layered materials based on calcium phosphates was written up. Based on knowledge obtained, experiments of preparation of calcium phosphates layered materials based on calcium phosphates by spin-coating method focused in optimalization of layer application conditions were designed and carried out. Experiments of preparation of hydroxyapatite bulk ceramics by uniaxial pressing followed by heat treatment were also performed. Prepared layered and bulk ceramics were characterized from bioactivity point of view by testing of their interaction with simulated body fluid.
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Shaping of bioceramics by dip-coating
Gockert, Radek ; Částková, Klára (referee) ; Salamon, David (advisor)
The presented bachelor thesis describes basic shaping methods of bioceramic materials, especially a description of the dip-coating method. Subsequently, the experimental part of the thesis presents the usage of this method for the preparation of ceramic micro units sintered from hydroxyapatite, and containing micro channel suitable for transporting media in living tissue. Tailoring of the process leads to the formation of variable droplets and films, subsequent sintering process used temperature control and calcination of the starting powder to achieve microstructure with controlled porosity and grain size. Micro units with diameter from 50 µm to 1 mm with variable porosity and micro channels were prepared from hydroxyapatite.
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Study of bioceramic composite based on hydroxyapatite and bioglass
Virágová, Eliška ; Hadraba, Hynek (referee) ; Drdlík, Daniel (advisor)
This bachelor thesis is focused on the bioceramic composite materials based on hydroxyapatite (HAp) and bioglass (BG). The wet shaping method, i.e. electrophoretic deposition (EPD), was chosen for the preparation of these materials. The methodology of preparation and its influence on kinetics, relative density and pore distribution in the prepared composites was evaluated. The sintering process of the prepared composites was studied using high temperature dilatometry with subsequent evaluation of their microstructural and mechanical features. It was found that EPD is an applicable method for successful preparation of the particle composites. The microstructural quality of particle composites was affected mainly by the electrical conductivity of the suspension. It was found during the study of EPD kinetics that the highest deposition rate was achieved in the suspension with the lowest electrical conductivity. Increasing amount of BG in HAp caused increase of the relative density and pore diameter whereas the volume of pores decreased. High temperature dilatometry showed a decrease of relative shrinkage, which was evident with increasing HAp amount in the structure. Observation of the microstructure revealed a crystalline structure of BG and an open porosity of HAp, which is desired for biocompatible materials. The phase composition of the materials was determined by X-ray diffraction analysis. In case of the mechanical properties it was found an increase of the hardness and Young’s modulus of elasticity with the increasing amount of BG in bioceramic composites. Based on the obtained results the suitable process and material composition for the planned preparation of the functionally graded material were identified.
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Bioceramic Materials and Their Biocopatibility with Bone Tissues
Novotná, Lenka ; Trunec, Martin (referee) ; Cihlář, Jaroslav (advisor)
The thesis concerns the study of ceramic coatings of zirconia nanoparticles deposited on alumina, zirconia and glass substrates by ultrasonic spraying. The quality of deposits was investigated in dependence on the type of substrate (composition, temperature, roughness) and concentration of ceramic suspension. The best results were received by the deposition of suspension of low concentration on rough substrates at low temperatures. The biocompatibility was tested in vitro. Good cytocompatibility of ceramics with nanostructure coatings was found.
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